Immunoglobulin

IgG

NCBI GENE nr

10454

Ab raised in

Rabbit

Protein nr

Q15750

Omim nr

5174703

Quantity per ml

1 mg/mL

French translation

anticorps

GENE symbol

MAP3K7IP1

Ncbi nr

NP_006107

Type

Polyclonal

Vial with antibody

in solution

Works with

Human, Mouse

Source

Homo sapiens

Antibodie's label

unlabelled serum

Suspention, pH, azide

TAB1 Antibody is supplied in PBS containing 0.02% sodium azide.

Immuno application

ELISA, Western Blot, immuno-cyto-chemistry, immuno fluorescence

Purity

TAB1 Antibody is affinity chromatography purified via peptide column.

Antigene name

mitogen-activated protein kinase kinase kinase 7 interacting protein 1

Antigen

TAB1 antibody was made against a synthetic peptide corresponding to 13 amino acids in the center of human TAB1.

Properties

If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

Description

This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.

Gene names

TAB1 Antibody: 3'-Tab1, MAP3K7IP1, TGF-beta-activated kinase 1 and MAP3K7-binding protein 1, Mitogen-activated protein kinase kinase kinase 7-interacting protein 1, TAK1-binding protein 1

Antibody advice

TAB1 antibody can be used for the detection of TAB1 by Western blot at 0.5 to 2 ug/mL. Antibody can also be used for immunocytochemistry starting at 1 ug/mL. For immunofluorescence start at 2 ug/mL.

Keep at

TAB1 antibody can be stored at 4 grades C for three months and -20 grades C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Gene info

TAB1 Antibody: TAB1 was identified as a regulator of the MAP kinase kinase kinase TAK1/MAP3K7, which is known to mediate various intracellular signaling pathways, such as those induced by TGF-beta and members of the Toll-IL-1R (TIR) superfamily, thus acting as an intermediate in both proliferative and innate and adaptive immune responses. This protein, together with either TAB2 or TAB3, activates TAK1 kinase in response to upstream signals. It has been shown that the C-terminal portion of TAB1 is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF-beta, demonstrating how this protein can function as a mediator between TGF-beta receptors and TAK1.