anti-TGFBR2 Antibody

7048

Human

Rabbit

P37173

TGFBR2

1 mg/ml

67782324

NP_003233

anticorps

Polyclonal

Lyophilized

Homo sapiens

62 kDa, 67 kDa

unlabelled serum

ELISA, Western Blot

transforming growth factor, beta receptor II (70/80kDa)

Antibody is purified by protein A chromatography method.

TGFBR2, HNPCC6, MFS2, RIIC, Tbeta, AAT3, FAA3, LDS1B, LDS2B, TAAD2, TGFR-2, TGFbeta-RII

Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human TGFBR2.

Antibody is lyophilized in PBS buffer with 2% sucrose. Add 100 μL of distilled water. Final antibody concentration is 1 mg/mL.

If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.

For short periods of storage (days) store at 4 grades C. For longer periods of storage, store TGFBR2 antibody at -20 grades C. As with any antibody avoid repeat freeze-thaw cycles.

TGFBR2 antibody can be used for detection of TGFBR2 by ELISA at 1:312500. TGFBR2 antibody can be used for detection of TGFBR2 by western blot at 5.0 ug/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

TGFBR2 is a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. The protein is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in its gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors.This gene is a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. It encodes a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein and binds TGF-beta. This receptor/ligand complex phosphorylates proteins which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.