Gene ID Number
7040
Modification Site
None
Swiss Prot
P01137
French translation
anticorps
Tested applications
IF(IHC-P)
Clonality
Polyclonal
Modification
Unmodified
Excitation emission
650nm/665nm
Immunogen range
280-330/390
Concentration
1ug per 1ul
Target Antigen
TGF Beta 1+2+3
Crossreactivity
Human, Mouse, Rat
Conjugated with
ALEXA FLUOR® 647
Clone
Polyclonal antibody
Recommended dilutions
IF(IHC-P)(1:50-200)
Purification
Purified by Protein A.
Subcellular location
Extracellular, Secreted
Conjugation
Alexa Fluor,ALEXA FLUOR 647
Category
Conjugated Primary Antibodies
Host Organism
Rabbit (Oryctolagus cuniculus)
Also known as
Anti-TGF Beta 1+2+3 PAb ALEXA FLUOR 647
Specificity
This is a highly specific antibody against TGF Beta 1+2+3.
Long name
TGF Beta 1+2+3 Polyclonal Antibody, ALEXA FLUOR 647 Conjugated
Synonyms
CED; LAP; DPD1; TGFB; TGFbeta; Transforming growth factor beta-1; TGF-beta-1; TGFB1
Cross-reactive species details
Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
Source
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human TGF Beta 1
Storage conditions
Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
Properties
For facs or microscopy Alexa 1 conjugate.Alexa Fluor 633 is a practical alternative to APC as well as Cy5. Bioss Primary Conjugated Antibodies. ALEXA FLUOR made this Alexa Fluor 633 conjugate that can be used in multi-color flow cytometry with instruments equipped with a second red laser or red diode. It is detected in the FL4 detector of the core's upgraded 2-laser FACScans. Like other Alexa Fluor dyes, the Anti-TGF Beta 1+2+3 exhibits uncommon photo stability, making it an ideal choice for fluorescent microscopy.If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
Background of the antigen
Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. Can promote either T-helper 17 cells (Th17) or regulatory T-cells (Treg) lineage differentiation in a concentration-dependent manner. At high concentrations, leads to FOXP3-mediated suppression of RORC and down-regulation of IL-17 expression, favoring Treg cell development. At low concentrations in concert with IL-6 and IL-21, leads to expression of the IL-17 and IL-23 receptors, favoring differentiation to Th17 cells.