TGF beta R2 Antibody, ALEXA FLUOR 350

None

7048

P37173

Cytoplasm

IF(IHC-P)

anticorps

Unmodified

Polyclonal

343nm/442nm

230-280/567

1ug per 1ul

Human, Mouse, Rat

ALEXA FLUOR® 350

Polyclonal antibody

IF(IHC-P)(1:50-200)

TGF beta Receptor II

Purified by Protein A.

Alexa Fluor,ALEXA FLUOR 350

Conjugated Primary Antibodies

Rabbit (Oryctolagus cuniculus)

Anti-TGF beta Receptor II PAb ALEXA FLUOR 350

TGF beta R2 Polyclonal Antibody, ALEXA FLUOR 350 Conjugated

This is a highly specific antibody against TGF beta Receptor II.

Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.

This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human TGF beta R2

Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.

AAT3; FAA3; LDS2; MFS2; RIIC; LDS1B; LDS2B; TAAD2; TGFR-2; TGFbeta-RII; TGF-beta receptor type-2; TGF-beta type II receptor; Transforming growth factor-beta receptor type II; TGF-beta receptor type II; TbetaR-II; TGFBR2

For facs or microscopy Alexa 1 conjugate.Alexa Fluor 350 conjugates can be used in multi-color flow cytometry with FACS's equipped with a second red laser or red diode.If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways.