Gene number

7040

Reacts with

Human

Raised in

Mouse

Protein number

P01137

French translation

anticorps

Latin name

Mus musculus

Research area

Growth Factors

Physical state

Colorless liquid

Purity

Affinity purified

Approved applications with antibody dilution

Western blot: 1-4 µg/ml

Immunogen

Recombinant human TGF-β1

Clonality

Monoclonal Antibody (Clone#3D9)

Antibody's positive controles

Western blot: HepG2 cell lysate

Delivery

Shipped to your lab under gel pack

Description

Mouse Monoclonal antibody to detect TGF-1

Released

This antibody is available to order since May 2017

Target

TGF-b1 (Transforming growth factor beta-1, TGF-beta-1, TGFB)

Precautions

Manifactured in USA. For Research Use Only! Not to be used in humans

Handling and storage

Before use gently mix the antibody solution. Store this antibody at -20 °C for 12 months. Refer to the label on vial

Properties

If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

Package form

Affinity purified antibody is supplied in liquid form in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol and 0.02% sodium azide.

Additional description

This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.

About

Monoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.

Test

Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.

Scientific context

TGF-β1 (transforming growth factor-beta) is a multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. It also stimulates sustained production of collagen through the activation of CREB3L1 by regulated intramembrane proteolysis.