Gene number
7040
Reacts with
Human
Raised in
Mouse
Protein number
P01137
French translation
anticorps
Latin name
Mus musculus
Research area
Growth Factors
Physical state
Colorless liquid
Purity
Affinity purified
Approved applications with antibody dilution
Western blot: 1-4 µg/ml
Immunogen
Recombinant human TGF-β1
Clonality
Monoclonal Antibody (Clone#3D9)
Antibody's positive controles
Western blot: HepG2 cell lysate
Delivery
Shipped to your lab under gel pack
Description
Mouse Monoclonal antibody to detect TGF-1
Released
This antibody is available to order since May 2017
Target
TGF-b1 (Transforming growth factor beta-1, TGF-beta-1, TGFB)
Precautions
Manifactured in USA. For Research Use Only! Not to be used in humans
Handling and storage
Before use gently mix the antibody solution. Store this antibody at -20 °C for 12 months. Refer to the label on vial
Properties
If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
Package form
Affinity purified antibody is supplied in liquid form in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol and 0.02% sodium azide.
Additional description
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
About
Monoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.
Test
Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
Scientific context
TGF-β1 (transforming growth factor-beta) is a multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. It also stimulates sustained production of collagen through the activation of CREB3L1 by regulated intramembrane proteolysis.