Excitation Emission
N/A
Gene ID number
9518
Modification site
None
Conjugation
Biotin
Swiss Prot
Q99988
Subcellular location
Secreted
Tested applications
WB, IHC-P
French translation
anticorps
Modification
Unmodified
Clonality
Polyclonal
Concentration
1ug per 1ul
Target Antigen
GDF15/MIC-1
Immunogen_range
260-308/308
Additional conjugation
Biotinylated
Crossreactivity
Human, Mouse, Rat
Clone
Polyclonal antibody
Category
Conjugated Primary Antibodies
Host Organism
Rabbit (Oryctolagus cuniculus)
Recommended dilutions
WB(1:100-1000), IHC-P(1:100-500)
Purification method
This antibody was purified via Protein A.
Long name
GDF15/MIC-1 Polyclonal Antibody, Biotin Conjugated
Specificity
This is a highly specific antibody against GDF15/MIC-1.
Source
KLH conjugated synthetic peptide derived from human GDF-15
Crossreactive species details
Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
Storage conditions
Keep the antibody in an aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store refrigerated at 2 to 8 degrees Celcius for up to 1 year.
Synonyms
PDF; MIC1; PLAB; MIC-1; NAG-1; PTGFB; GDF-15; Growth/differentiation factor 15; Macrophage inhibitory cytokine 1; NSAID-activated gene 1 protein; NSAID-regulated gene 1 protein; NRG-1; Placental TGF-beta; Placental bone morphogenetic protein; Prostate differentiation factor; GDF15
Properties
If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.Biotin conjugates can be detected by horseradish peroxidase, alkaline phosphatase substrates or anti biotin conjugated antibodies. Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA. To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1.6.
Antigen background
Growth differentiation factor 15 (GDF15) is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. It has been implicated in a variety of functions directly related to tumorigenicity including antiproliferative and pro-apoptotic effects. BMP proteins are secreted growth factors that are characterized by seven conserved cysteine residues. In general, they are regulators of cell growth and differentiation in both embryonic and adult tissues.GDF15 is an important downstream mediator of DNA damage signaling and a transcriptional target of p53.