Gene ID number
9518
Conjugation
FITC
Modification site
None
Swiss Prot
Q99988
Subcellular location
Secreted
Tested applications
IF(IHC-P)
French translation
anticorps
Modification
Unmodified
Clonality
Polyclonal
Concentration
1ug per 1ul
Excitation Emission
494nm/518nm
Target Antigen
GDF15/MIC-1
Immunogen_range
260-308/308
Crossreactivity
Human, Mouse, Rat
Additional conjugation
Anti-FITC Antibody
Recommended dilutions
IF(IHC-P)(1:50-200)
Clone
Polyclonal antibody
Category
Conjugated Primary Antibodies
Host Organism
Rabbit (Oryctolagus cuniculus)
Purification method
This antibody was purified via Protein A.
Long name
GDF15/MIC-1 Polyclonal Antibody, FITC Conjugated
Specificity
This is a highly specific antibody against GDF15/MIC-1.
Source
KLH conjugated synthetic peptide derived from human GDF-15
Crossreactive species details
Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
Storage conditions
Keep the antibody in an aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store refrigerated at 2 to 8 degrees Celcius for up to 1 year.
Synonyms
PDF; MIC1; PLAB; MIC-1; NAG-1; PTGFB; GDF-15; Growth/differentiation factor 15; Macrophage inhibitory cytokine 1; NSAID-activated gene 1 protein; NSAID-regulated gene 1 protein; NRG-1; Placental TGF-beta; Placental bone morphogenetic protein; Prostate differentiation factor; GDF15
Antigen background
Growth differentiation factor 15 (GDF15) is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. It has been implicated in a variety of functions directly related to tumorigenicity including antiproliferative and pro-apoptotic effects. BMP proteins are secreted growth factors that are characterized by seven conserved cysteine residues. In general, they are regulators of cell growth and differentiation in both embryonic and adult tissues.GDF15 is an important downstream mediator of DNA damage signaling and a transcriptional target of p53.
Properties
If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.This Bioss Primary Conjugated Antibodies Fluorescein isothiocyanate (FITC) antibody is currently after some BD antibodies the most commonly used fluorescent dye for FACS. When excited at 488 nanometers, FITC has a green emission that's usually collected at 530 nanometers, the FL1 detector of a FACSCalibur or FACScan. FITC has a high quantum yield (efficiency of energy transfer from absorption to emission fluorescence) and approximately half of the absorbed photons are emitted as fluorescent light. For fluorescent microscopy applications, the 1 FITC is seldom used as it photo bleaches rather quickly though in flow cytometry applications, its photo bleaching effects are not observed due to a very brief interaction at the laser intercept. Bioss Primary Conjugated Antibodies FITC is highly sensitive to pH extremes.