Raised in

Rabbit

Protein number

P04202

Use before

1 year

Shipping requirements

Blue ice

French translation

anticorps

Clonality

Polyclonal

Verified reactivity

Mouse, human

Estimated production time

3-7 business days

NCBI number

Please refer to NCBI

Gene number

Please refer to GenBank

Purity

Protein G purified,>95%

Group

Polyclonals and antibodies

Other name

Transforming growth factor beta-1TGF-beta-1,Tgfb1

Notes

For research use only. Not for diagnostic procedures.

Storage recommendation

Aliquot and store at -20°C. Minimize freezing and thawing.

Verified applications

ELISA,WB,IP. Recommended dilution:WB:1:500-1:5000,IP:1:200-1:2000

Immunogen

Recombinant Mouse Transforming growth factor beta-1 protein (30-391AA)

Properties

If you buy Antibodies supplied by bioma they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

About

Polyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera.

Supplementary information

Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. Can promote either T-helper 17 cells (Th17) or regulatory T-cells (Treg) lineage differentiation in a concentration-dependent manner. At high concentrations, leads to FOXP3-mediated suppression of RORC and down-regulation of IL-17 expression, favoring Treg cell development. At low concentrations in concert with IL-6 and IL-21, leads to expression of the IL-17 and IL-23 receptors, favoring differentiation to Th17 cells (PubMed:18368049). Mediates SMAD2/3 activation by inducing its phosphorylation and subsequent translocation to the nucleus. Can induce epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types (By similarity).