This antibody reacts with:

Human

Antibody host:

Rabbit

Form of antibody:

Liquid

Shipping conditions:

gel pack

French translation

anticorps

Concentration of antibody:

0.5 mg/ml

Clonality of antibody:

Polyclonal

Isotype:

Rabbit IgG

This antibody has been succesfully tested for use in following methods:

Western blot

Target of this antibody:

TGF-b Receptor I

Purification method:

Affinity purified

Storage information:

Shelf time: 12 months in temp.: -20 deg.C

How to handle this antibody:

The antibody solution should be gently mixed before use.

Immunogene sequence:

Synthetic peptide surrounding amino acid 411 of human TGF-β Receptor I

Properties

If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

Formulation of this antibody:

30 µg (0.5 mg/ml) affinity purified rabbit polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.

Alternative names of antibody target:

Transforming growth factor beta receptor I, TGFR1, TGFR-1, TGFR 1, TGF beta receptor type 1, TbetaR I , Serine/threonine-protein kinase receptor R4, SKR4, SKR 4, SKR-4

Recommended usage:

Western blotting (0.5-4 µg/ml) and Immunohistochemistry (5 µg/ml). However, the optimal conditions should be determined individually. antibody detects 30 and 55 kDa isoforms of TGF-β Receptor I on SDS-PAGE immunoblots in samples from human, mouse, rat, pig and bovine origins.

Background information:

TGF-β (Transforming growth factor-beta superfamily members are critical regulators of cell proliferation, differentiation, morphogenesis, and pathogenesis. TGF-beta receptor is a serine/threonine kinase receptor complex that consists of two distinct transmembrane proteins known as type I and type II receptors. In response to ligand binding, the type II receptors form a stable complex with the type I receptors allowing phosphorylation and thus activation of the type I receptor kinases.

Description

This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.