TGF Beta 1+2+3 Antibody, Cy3 Conjugated

Cy3

7040

None

P01137

IF(IHC-P)

anticorps

Unmodified

Polyclonal

280-330/390

1ug per 1ul

TGF Beta 1+2+3

Human, Mouse, Rat

cy3 conjugation kit

IF(IHC-P)(1:50-200)

512,550nm/570,615nm

Polyclonal antibody

Extracellular, Secreted

Conjugated Primary Antibodies

Rabbit (Oryctolagus cuniculus)

This antibody was purified via Protein A.

TGF Beta 1+2+3 Polyclonal Antibody, Cy3 Conjugated

KLH conjugated synthetic peptide derived from human TGF Beta 1

CED; LAP; DPD1; TGFB; TGFbeta; Transforming growth factor beta-1; TGF-beta-1; TGFB1

Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.

Keep the antibody in an aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store refrigerated at 2 to 8 degrees Celcius for up to 1 year.

This is a highly specific antibody against TGF Beta 1+2+3. This antibody will preferentially react with TGFB1, but will also detect TGFB2 (93%) and TGFB3 (86%) based upon sequence similarity.

If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.Cy3 antibodies are excited by the 488-nanometer wave of an argon laser and the 633-nanometer line of a helium-neon diode laser. 1 of the Anti-TGF Beta 1+2+3 can be used in flow cytometry but typically shows lower fluorescence intensity comparable to that of PE or APC. This Bioss Primary Conjugated Antibodies antibody is well suited for fluorescent microscopy.

Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. Can promote either T-helper 17 cells (Th17) or regulatory T-cells (Treg) lineage differentiation in a concentration-dependent manner. At high concentrations, leads to FOXP3-mediated suppression of RORC and down-regulation of IL-17 expression, favoring Treg cell development. At low concentrations in concert with IL-6 and IL-21, leads to expression of the IL-17 and IL-23 receptors, favoring differentiation to Th17 cells.