TGFBR2 Antibody

WB

TGFBR2

P37173

Antibody

anticorps

Unconjugated

Antigen affinity

Polyclonal antibody

Western blot: 0.5-1ug/ml

Antigen affinity purified

Polyclonal (rabbit origin)

Rabbit (Oryctolagus cuniculus)

0.5mg/ml if reconstituted with 0.2ml sterile DI water

This TGFBR2 antibodyis to be used only for research purposes and not for diagnostics..

If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

The stated application concentrations are suggested starting amounts. Titration of the TGFBR2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

An amino acid sequence from the middle region of human TGF beta Receptor II (KGNLQEYLTRHVISWED) was used as the immunogen for this TGFBR2 antibody (100% homologous in human, mouse and rat).

Human (Homo sapiens), Mouse (Mus musculus), Rat ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.

After reconstitution, the TGFBR2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized. Avoid repeated freezing and thawing.

Transforming growth factor, beta receptor II, also known as TGFBR2 and TGFR-2, is a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. A TGFBR2 cDNA encoding a deduced 565-amino acid protein with a calculated molecular mass of approximately 60 kD in length. The encoded protein is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in this gene have been associated withMarfan syndrome,Loeys-Deitz aortic aneurysm syndrome,Osler-Weber-Rendu syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized. TGFBR2 may be a target of the EWS-FLI1 fusion protein found in Ewing sarcoma and related peripheral primitive neuroectodermal tumors.